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Copyright ©The Author(s) 2023.
World J Stem Cells. Mar 26, 2023; 15(3): 83-89
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.83
Table 1 Summary of studies on mesenchymal stem cells-derived exosomes in osteoporosis treatment
Ref.
Exosome source
Cell type
Consequence
Zuo et al[24], 2019BMSCsBMSCs (after irradiation)Alleviating radiation-induced bone loss by restoring Wnt/β-Catenin signaling pathway
Zhao et al[25], 2018BMSCsOsteoblasts (hFOB 1.19)Promoting proliferation of osteoblasts via MAPK pathway
Liao et al[26], 2019BMSCsOsteoblastsPromoting proliferation of osteoblasts by carrying miR-122-5p
Qi et al[27], 2016hiPSC-MSCsOsteoblastsPromoting osteoblast proliferation, differentiation and bone formation
Hu et al[28], 2021BMSCsOsteoblastsPromoting differentiation of osteoblasts by carrying miR-335
Zhang et al[31], 2021AD-MSCsOsteoclastsInhibiting NLRP3 inflammasome activation in osteoclasts
Nakao et al[32], 2021GMSCsOsteoclastsInhibiting RANKL and reducing osteoclast formation by carrying miR-1260b via Wnt5a/JNK signal pathway
Xu et al[33], 2018BMSCsOsteoclastsIncreasing the number of osteoclasts by carrying miR-31a-5p via RhoA pathway
Wei et al[40], 2019BMSCsOsteoblastsPromoting osteoblast differentiation by inhibiting macrophage polarization and reducing the levels of inflammatory factors