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©The Author(s) 2023.
World J Stem Cells. Mar 26, 2023; 15(3): 31-51
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.31
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.31
Table 4 Dental stem cell-based clinical trials registered on the International Clinical Trials Registry Platform
Ref. | Registration ID | Status | Diseases | Study design | Cell source | Administration route | Number of patients | Interventions | Follow-up period | Phase | Outcomes | |
Test group | Control group | |||||||||||
- | JPRN-UMIN000042791 | Complete: Follow-up complete | Periodontitis | Randomized; parallel assignment; single-blind (participants) | Deciduous pulp | Gargle | 30 | Mouthwash containing SHED culture supernatant | Mouthwash without SHED culture supernatant | 1 mo | Not applicable | |
- | ChiCTR2100051466 | Recruiting | Periodontitis | Randomized; parallel assignment; open label | Dental pulp | Bilateral multipoint injection on a single tooth | 96 | DPSCs (1 × 107 cells) for once; DPSCs (1 × 107 cells) for twice | Saline | 90, 180, 360 d | Phage 0 | |
- | ChiCTR2100049178 | Pending | Periodontitis | Randomized; parallel assignment; double-blind | Dental pulp | Local injection | 36 | DPSCs (1 × 106 cells) for single injection; DPSCs (5 × 106 cells) for single injection; DPSCs (1 × 107 cells) for single injection; DPSCs (1 × 107 cells) for single injection in 2 locations; DPSCs (1 × 107 cells) for single injection in 3-4 locations | None | Phage 1 | ||
Sánchez et al[42], 2020 | ISRCTN13093912 | Completed | Periodontitis | Randomized; parallel assignment; single-blind (patients and examiners) | Dental pulp | Implanted into bone defect sites via surgical approach | 20 | DPSCs (1 × 107 cells) + hydroxyapatite-collagen scaffold | Hydroxyapatite-collagen scaffold | 1, 2, 4, 12, 24, 36 wk; 12, 24, 36, 48, 60 mo | Not applicable | |
- | JPRN-UMIN000045926 | Complete: Follow-up complete | Wrinkles | Randomized; parallel assignment; single-blind (outcomes assessor) | Dental pulp | 12 | All-in-one gel containing immortalized DPSCs-CM solution and various beauty ingredients | No treatment | 4 wk | Not applicable | ||
- | JPRN-UMIN000043528 | Complete: Follow-up complete | Wrinkles | Randomized; parallel assignment; single-blind (outcomes assessor) | Dental pulp | 12 | All-in-one gel containing immortalized DPSC-CM solution and the latest peptide raw materials | No treatment | 4 wk | Not applicable | ||
- | JPRN-UMIN000045897 | Complete: Follow-up continuing | Hair loss | Nonrandomized; parallel assignment; open label | Deciduous pulp | Injection | 22 | SHED-CM; after SHED-CM injection, one dose of micrografts (Rigenera) followed by another SHED-CM injection; SHED-CM injection after one dose of micrografts (Rigenera) | None | 6 mo | Not applicable |
- Citation: Song WP, Jin LY, Zhu MD, Wang H, Xia DS. Clinical trials using dental stem cells: 2022 update. World J Stem Cells 2023; 15(3): 31-51
- URL: https://www.wjgnet.com/1948-0210/full/v15/i3/31.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v15.i3.31