Review
Copyright ©The Author(s) 2023.
World J Stem Cells. Mar 26, 2023; 15(3): 31-51
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.31
Table 1 Characteristics of different types of dental stem cells
Cell types
Markers
Multidirectional differentiations
Cell surface markers
Embryonic stem cell markers
Nerual markers
DPSCsCD13, CD29, CD44, CD59, CD73, CD90, CD105, CD146, STRO-1[7], CD81, CD49f[140], CD40, CD120a, CD261, CD262, CD264, CD266, CD121a, CD130, CD213a1, CD217, CDw210b[141]OCT-4, Nanog[142], SSEA-1, SEEA-4[140], SOX-2[143]βIII-tubulin, NFM, Nestin, CNPase[144], S100, CD271[17]Osteogenic, Odontogenic[145], Dentinogeni, Chondrogenic, Neurogenic, Myogenic, Adipogenic[13], Hepatogenic[146]
PDLSCsCD13, CD29, CD44, CD49, CD73, CD90, CD105, CD146, CD166, CD271[147], CD10[7], STRO-1[148]SSEA-1, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, OCT-4, Nanog, SOX-2, REX1, and ALP[149]Nestin, OCT-4, SSEA-4[9] CD271, SOX-10[147], SOX-2[149]Osteogenic, Cementogenic, Adipogenic, Chondrogenic, Neurogenic[13], Hepatogenic[149], Cardiac myogenic, Endothelial-like, Islet-like, Retinal ganglion-like[147]
SCAPCD13, CD24, CD29, CD44, CD49, CD51, CD56, CD61, CD73, CD90, CD105, CD106, CD146, CD166, STRO-1, NOTCH-3[150], CD81, CD49f[151]OCT-4, Nanog, SOX2[143], CD49f[151]βIII-tubulin, NFM, Nestin, CNPase[144], SOX-2[143], Vimentin, Survivin[150]Osteogenic, Dentinogenic, Adipogenic[15], Neurogenic[13], Chondrogenic, Hepatogenic[150]
SHEDCD29, CD73, CD90, CD166[13], STRO-1, CD44[145], CD105[152], NOTCH-1, CD10, CD13, CD34, CD106, CD146, CD166, CD271[102]OCT-4, Nanog, SSEA-3[153], SSEA-4[152], NOTCH-1, OCT-4, SOX-2[102]βIII-tubulin, NFM, Nestin, CNPase, GAD, NeuN, GFAP[154], CD271, Vimentin, OCT-4, PAX-6, NSE, MAP-2, PSA-NCAM, TH[102]Osteogenic, Odontogenic[145], Dentinogenic, Chondrogenic, Neurogenic, Myogenic, Adipogenic[13], Hepatogenic[155]
DFPCsCD13, CD29, CD59, CD90[7], CD105, CD146[142], CD44, CD73, NOTCH-1, STRO-1[156]OCT-4, Nanog[142], NOTCH-1, SOX-2[156]OCT-4, SOX2[9], Nestin, SOX-2[156]Osteogenic, Cementogenic, Odontogenic, Adipogenic, Chondrogenic[13], Hepatogenic[146]
GMSCsCD13, CD29, CD44, CD73, CD90, CD105, CD146, STRO-1[16]SSEA-4[16], OCT-4, Nanog[157]Nestin, SOX10[16], βIII-tubulin, NFM, CNPase[144]Osteogenic, Adipogenic, Chondrogenic, Neurogenic, Endothelial-like, Odontogenic[16], Myogenic[158]
ALP: Alkaline phosphatase; CD: Cluster of differentiation; CNPase: 2’,3’-cyclic nucleotide 3’-phosphodiesterase; GAD: Glutamic acid decarboxylase; GFAP: Glial fibrillary acidic protein; MAP-2: Microtubule associated protein 2; NeuN: Neuronal nuclei; NFM: Neurofilament medium chain; NGFR: Nerve growth factor receptor; NSE: Neuron-specific enolase; OCT: Octamer-binding transcription factor; PAX-6: Paired Box 6; PSA-NCAM: Polysialylated neural cell adhesion molecule; REX-1: RNA exonuclease 1 homolog; SOX: Sex determining region Y-box; SSEA: Stage-specific embryonic antigen; TH: Tyrosine hydroxylase; SHED: Stem cells from exfoliated deciduous teeth.