ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors

Figure 6 The expression of lactate dehydrogenase, neurotrophic factor and apoptosis-related protein and mRNA. A: Lactate dehydrogenase (LDH) expression level in each group was measured by the LDH test kit; B: The expression of apoptosis-related proteins and neurotrophic factors were detected by western blotting; C: The mRNA expression of apoptosis-related proteins and neurotrophic factors were detected by real-time quantitative polymerase chain reaction. ^aP,^bP, ^cP, ^dP, ^eP, ^fP, ^gP, ^hP, ⁱP, and ^jP < 0.05, represent the comparison of caspase3, caspase9, B-cell lymphoma 2, Bax, tropomyosin receptor kinase (TrK)A, TrKB, brain-derived neurotrophic factor, cyclic adenosine monophosphate response element-binding protein, ciliary neurotrophic factor, and nerve growth factor proteins between the two groups. ADSC: Adipose-derived stem cell; BMSC: Bone marrow-derived stem cell; Exo: Exosome; NC: Normal control; LDH: Lactate dehydrogenase; Bcl2: polyvinylidene fluoride; Trk: Tropomyosin receptor kinase; BDNF: Brain-derived neurotrophic factor; CREB: Cyclic adenosine monophosphate response element-binding protein; CNTF: Ciliary neurotrophic factor; NGF: Nerve growth factor.