MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells

doi:10.4252/wjsc.v15.i10.979

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Oct 26, 2023 (publication date) through Nov 23, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Oct 26, 2023; 15(10): 979-988
Published online Oct 26, 2023. doi: 10.4252/wjsc.v15.i10.979

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Figure 6 The interregulation of microRNA-584-5p/RUNX family transcription factor 2 on hypoxia-induced periosteal stem cell osteogenic differentiation. The hypoxic environment induces periosteal stem cells to undergo osteogenic differentiation by activating the RUNX family transcription factor 2 (RUNX2)-related pathway; however, miR-584-5p overexpression can inhibit osteogenic differentiation by downregulating RUNX2 expression. PSC: Periosteal stem cell.

Citation: Lu JJ, Shi XJ, Fu Q, Li YC, Zhu L, Lu N. MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells. World J Stem Cells 2023; 15(10): 979-988
URL: https://www.wjgnet.com/1948-0210/full/v15/i10/979.htm
DOI: https://dx.doi.org/10.4252/wjsc.v15.i10.979