How mesenchymal stem cell cotransplantation with hematopoietic stem cells can improve engraftment in animal models

Table 1 Characteristics of hematopoietic stem cells

Ref.	Year	Hematopoietic stem cells			Transplantation
		Donor	Source	Lineage	Cell dose	Route	Volume (µL)
Lee et al[9]	2021	Mice (C57BL/6)	BM	NC	1 × 107	IV	NR
Huang et al[10]	2021	Human	UCB	MNC	1 × 107	IV; IB	200; NR
Yin et al[8]	2020	Human	UCB	CD34+	2.5 × 103; 5 × 103; 1 × 104; 2 × 104	IV; IB	NR; 10
Choi et al[11]	2020	Mice (C57BL/6)	BM	NC	1 × 107	IV	200
Trento et al[12]	2017	Mice (C57BL/6 CD45.1)	BM	NC	2 × 106	IV	NR
Abbuehl et al[13]	2017	Mice (FVB Actin-GFP)	BM	NC	5 × 106	IV	100
Kim et al[14]	2016	Mice (C57BL/6J-Pep3b-Ly5.1 Pep3b)	BM	NC	2 × 104	NR	NR
Futrega et al[15]	2016	Human	UCB	CD34+	5 × 104	IV; IB	100; 10
van der Garde et al[16]	2015	Human	UCB	CD34+	2 × 105	IV	NR
Fernández-García et al[17]	2015	Mice (P3D2F1 H2b/d CD45.1)	BM	LSK	1.5 × 104	NR	NR
Chen et al[18]	2015	Mice (C57BL/6)	BM	NC	5 × 106	IV	NR
Chen et al[19]	2014	Human	UCB	CD34+	1 × 105	IV	NR
Wu et al[20]	2013	Human	UCB	NC	1 × 106	IV	250
Lim et al[21]	2013	Human	UCB	MNC	1 × 107	IV	200
Lee et al[22]	2013	Human	UCB	CD34+	2 × 105	IV	150-200
Kornblit et al[23]	2013	Dog (beagle)	BM	NC	1.8-5.3 × 108/kg	IV	50 mL
Fortin et al[24]	2013	Mice (B6.SJL-PtrcaPep3b/BoyJ CD45.1)	BM	NC	2 × 106	IV	NR
Carrancio et al[25]	2013	Human	UCB	CD34+	1 × 105	IV; IB	200; 20

BM: Bone marrow; MNC: Mononuclear cells; NC: Nucleated cells; UCB: Umbilical cord blood; LSK: Lineage^- Sca-1+ cKit+; IV: Intravenous; IB: Intrabone; NR: Not reported.