Metabolic determinants of stemness in medulloblastoma

doi:10.4252/wjsc.v14.i8.587

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Aug 26, 2022 (publication date) through May 7, 2025

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Aug 26, 2022; 14(8): 587-598
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.587

Table 2 Metabolic therapeutic targeting in medulloblastoma

MB group	MB		MB-CSCs
MB group	General drug (target)	Group specific drug (target)	General drug (target)	Group specific drug (target)
WNT[2]	C75 (FASN)[36], Oxamate (LDH)[41], DFMO (ODC)¹, Isotretinoin (RAR, RXR)¹		DCA (PDK)[54]; Curcumin (pleiotropic)[73]; IP6 (mTOR)[55]
SHH[2]		GW9662 (PPARγ)[39]
Group 3[2]		GSK2837808a, FX11 (LDHA)[43]; TAK228, Sirolimus, Temsirolimus, Everolimus (mTOR)[71]; JHU395 (Glutamine)[72]		WP1066 (STAT3) & Chloroquine (autophagy)[58]
Group 4[2]

¹Compounds tested in clinical trials. DCA: Dichloroacetic acid; DFMO: Difluoromethylornithine; FASN: Fatty acid synthase; LDH: Lactate dehydrogenase; MB: Medulloblastoma; MB-CSCs: Medulloblastoma cancer stem cells; mTOR: Mammalian target of rapamycin; ODC: Ornithine decarboxylase; PPARγ: Peroxisome proliferator-activated receptor gamma; RAR: Retinoic acid receptor; RXR: Retinoid X receptor; STAT3: Signal transducer and activator of transcription 3.

Citation: Martín-Rubio P, Espiau-Romera P, Royo-García A, Caja L, Sancho P. Metabolic determinants of stemness in medulloblastoma. World J Stem Cells 2022; 14(8): 587-598
URL: https://www.wjgnet.com/1948-0210/full/v14/i8/587.htm
DOI: https://dx.doi.org/10.4252/wjsc.v14.i8.587