Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways

Figure 2 Human umbilical cord-derived mesenchymal stem cells administration increases survival rate and improves lung development. A: Schematic diagram of the overall experimental design process and grouping; B: Kaplan-Meier survival curves of rat pups treated as indicated; C: Body weight alterations of rat pups treated as indicated; D: Representative images of harvested lung sections stained with hematoxylin and eosin for morphometric analyses (scale bars = 100 μm); E and F: Mean linear intercept and septal counts in lungs treated as indicated (n = 5 for each group, 10 fields/animal). ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. iT: Intratracheal; iP: Intraperitoneal; P: Postnatal day; PBS: Phosphate-buffered saline; MSC: Mesenchymal stem cell.