miR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc

Figure 1 High expression of miR-3682-3p reflected poor prognosis of hepatocellular carcinoma. A: The expression levels of miR-3682-3p in normal and hepatocellular carcinoma (HCC) tissues in The Cancer Genome Atlas (TCGA) dataset; B: The expression of miR-3682-3p in 34 HCC and paired paracancerous tissue samples as determined by RT-qPCR; C: miR-3682-3p expression in HCC cells (HepG2, Huh7, Hep3B, LM3, and MHCC-97H) and normal liver epithelial (LO2) cells as determined by RT-qPCR; D: Analysis of Kaplan-Meier overall survival curves for HCC patients based on miR-3682-3p expression in TCGA dataset. ^bP < 0.01, ^cP < 0.001. Experiments were repeated three times.