miR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc

Table 2 Univariate and multivariate survival analysis of clinicpathological variables of hepatocellular carcinoma patients

Characteristics	Overall survival
	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
FOXO3 expression	0.311	(0.134-0.721)	0.006	0.504	(0.164-1.553)	0.233
Low vs high
Age (yr)	0.721	(0.352-1.476)	0.371
≤ 50 vs > 50
Gender	0.520	(0.124-2.176)	0.371
Male vs female
AJCC stage	2.277	(1.123-4.616)	0.022	1.203	(0.555-2.604)	0.640
I vs II-III
HBsAg	0.667	(0.257-1.736)	0.407
Negative vs positive
Recurrence	87.223	(4.860-1565.443)	0.002
No vs yes
AFP (ng/mL)	0.888	(0.434-1.818)	0.746
≤ 400 vs > 400
Total bilirubin (μmol/L)	1.113	(0.428-2.893)	0.826
≤ 20 vs > 20
ALT (U/L)	1.046	(0.504-2.171)	0.903
≤ 45 vs > 45
GGT (U/L)	0.386	(0.159-0.937)	0.035	0.594	(0.233-1.516)	0.276
≤ 40 vs > 40
Edmondson-Steiner grade	3.664	(1.791-7.497)	< 0.001	1.839	(0.560-3.445)	0.478
I-II vs III-IV
Tumor number	1.810	(0.742-4.417)	0.192
Singlevs vs multiple
Tumor size (cm)	0.504	(0.250-1.018)	0.056
≤ 5 vs > 5