Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

Table 1 Functional categories and annotations in ingenuity pathway analyses of genes regulated by hypoxia-inducible factor 1A

Categories	P value	Top five functional annotations	Number of genes
Carbohydrate Metabolism	3.50E-20	Glycolysis of cells	22
Cardiovascular System Development and Function	3.31E-15 to 4.96E-54	Angiogenesis, Vasculogenesis, Growth of blood vessel	84
Cell Cycle	7.42E-16 to 1.82E-38	Binding of DNA, Cell cycle progression, Interphase, Binding of protein binding site, Arrest in interphase	99
Cell Death and Survival	3.79E15 to 7.3E-74	Apoptosis, Necrosis, Cell death of tumor cell lines, Apoptosis of tumor cell lines, Cell viability	150
Cell Morphology	1.66E-16 to 3.21E-24	Morphology of tumor cell lines, Tubulation of cells, Transmembrane potential of mitochondria, Cell spreading, Orientation of cells	77
Cell Signaling	2.83E-19 to 1.1E-26	Cytokine and chemokine mediated signaling pathway, Quantity of Ca2+	48
Cell-To-Cell Signaling and Interaction	3.31E15 to 1.99E-36	Binding of tumor cell lines, Binding of blood cells, Adhesion of blood cells, Binding of leukocytes, Adhesion of immune cells	105
Cellular Assembly and Organization	5.56E-16 to 1.42E-17	Organization of cytoskeleton, Microtubule dynamics, Fibrogenesis	52
Cellular Development	3.47-15 to 2.85E-73	Cell proliferation of tumor cell lines, Cell proliferation of carcinoma cell lines, Cell proliferation of breast cancer cell lines, Proliferation of muscle cells, Assembly of cells	151
Cellular Function and Maintenance	7.07E-32	Cellular homeostasis	67
Cellular Growth and Proliferation	9.07E-27 to 2.12E-30	Proliferation of vascular cells, Colony formation, Proliferation of connective tissue cells, Proliferation of lymphatic system cells, Proliferation of epithelial cells	101
Cellular Movement	3.31E-15 to 3.35E-67	Cell movement, Migration of cells, Invasion of cells, Cell movement of tumor cell lines, Migration of tumor cell lines	132
Connective Tissue Development and Function	1.36E-16 to 1.73E-30	Growth of connective tissue, Quantity of connective tissue	46
DNA Replication, Recombination, and Repair	1.67E-18 to 8.06E-31	Synthesis of DNA, Metabolism of DNA, Degradation of DNA	47
Drug Metabolism, Lipid Metabolism, Small Molecule Biochemistry	2.36E-16	Synthesis of prostaglandin E2	16
Free Radical Scavenging	6.09E-16 to 5.5E-33	Synthesis of reactive oxygen species, Production of reactive oxygen species, Generation of reactive oxygen species, Quantity of reactive oxygen species	43
Gene Expression	1.373-18 to 4.01E-31	Expression of RNA, Transcription, Transcription of RNA, Transactivation, Transactivation of RNA	88
Inflammatory Response	5.48E-20 to 2.72E-26	Inflammation of absolute anatomical region, Inflammation of organ, Inflammatory response, Inflammation of body cavity, Immune response of cells	77
Lipid Metabolism	6.24E-16 to 9.37E-24	Synthesis of eicosanoid, Metabolism of eicosanoid, Fatty acid metabolism, Synthesis of fatty acid, Synthesis of prostaglandin	48
Organismal Survival	9.55E-37 to 2.76E-39	Organismal death, Survival of organism	81
Post-Translational Modification	1.86E-18	Phosphorylation of protein	34
Protein Synthesis	2.10E-15	Metabolism of protein	44
Tissue Development	1.65E-19 to 4.13E-46	Growth of epithelial tissue, Development of epithelial tissue, Growth of nervous tissue	62
Tissue Morphology	3.02E-17 to 3.06E-26	Quantity of cells, Quantity of tumor cell lines	42