Application and prospects of high-throughput screening for in vitro neurogenesis

Figure 3 Summary of high-throughput screening platforms and their functions. Cell-free, cell-based and organoid-based HTS platforms can screen out target small molecules, genes, biomaterials and microenvironments to promote the survival, proliferation, differentiation and maturation of pluripotent stem cells, induce the transdifferentiation of somatic cells to other cell types, and even generate specific organoids for further applications, including disease modeling, development modeling, drug screening, tissue engineering and regenerative medicine. High-throughput screening (HTS) platforms include multiwell plates, microarrays and microfluidic chips, indicating the great potential in HTS in future studies. HTS: High-throughput screening; ECM: Extracellular matrix.