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©The Author(s) 2022.
World J Stem Cells. Jun 26, 2022; 14(6): 372-392
Published online Jun 26, 2022. doi: 10.4252/wjsc.v14.i6.372
Published online Jun 26, 2022. doi: 10.4252/wjsc.v14.i6.372
Table 2 Clinical trials using adipose-derived mesenchymal stem cells for bone regeneration registered on clinicaltrials.gov (June 2021)
Trial registration | Ref. | Study design | Group/cohort | Intervention | Location | Status |
NCT01218945 | Calcagni[168] | Observational/prospective | Overweight, non-metabolic disease, 17-80 yr | To pre-engineer large synthetic bone grafts and study the vascularization process in vivo | University of Zurich, Switzerland | Completed December 2012 |
NCT01532076 | Saxer and Jakob[169] | Allocation: Randomized. Intervention model: Parallel assignment. Masking: Single (outcomes assessor). Primary purpose: Treatment | Patients with osteoporotic fractures, age 18-70 yr | Cellularized composite graft augmentation liposuction, cell isolation, embedding of SVF cells in fibrin gel, wrapping around hydroxyapatite granules compared to acellular grafts | University Hospital, Basel, Switzerland | Terminated/slow recruitment rate/last update 17 September 2014 |
NCT01643655 | Yoon[170] | Allocation: N/A. Intervention model: Single group assignment. Masking: None (open label). Primary purpose: Treatment | Avascular necrosis femoral head Steinberg I-III/pre-collapse, age 17-70 yr | Autologous adipose tissue-derived MSCs transplantation into the femoral head/infusion of autologous adipose-derived mesenchymal stem cells. Dose: 1 × 108 cells/3 mL | R-Bio SMG-SNU Boramae Medical Center | Recruitment completed/last update 31 August 2017 |
NCT02140528 | Gourabi et al[171] | Allocation: Randomized. Intervention model: Parallel assignment. Masking: Double (participant, investigator). Primary purpose: Treatment | Closed shaft tibial fracture, age 18-65 yr | Injection of adipose-derived mesenchymal stem cell in the site of tibia fracture. Other name: Stem cell transplantation compared to Placebo | Royan Institute Tehran, Iran | Completed/last update 27 April 2017 |
NCT03269409 | Sierra[172] | Interventional, allocation: Randomized. Intervention model: Parallel assignment. Masking: Quadruple (participant, care provider, investigator, outcomes assessor). Primary purpose: Treatment | Patients with ONFH pre-collapse, non-posttraumatic, 22-70 yr of age | Adipose-derived regenerative cells harvested through autologous liposuction processed using the Celution 800/GP System (Cytori Therapeutics) transplanted into the femoral head after standard of care hip decompression compared to standard decompression and Ringer solution | Mayo Clinic, United States | Suspended (updating study protocol, consent form and study SOP protocol) March 2021 |
NCT02307435 | Dilogo[173] | Allocation: N/A. Intervention model: Single group assignment. Masking: None (open label). Primary purpose: Treatment | Fracture nonunion metaphyseal fibrous defect, age 19-30 yr | Experimental: Implantation group implantation group will receive ADSC/UCMASC/BMSCs and HA-CaSO4. Intervention: Biological: MSC | University of Indonesia, Jakarta | Unknown/last update 4 December 2014 |
NCT03678831 | Pasquier[174] | Observational, case-control prospective | Arthritic post-menopausal patients with knee prosthetic replacement | Adipocyte isolation from distal femoral epiphysis and subcutaneous adipose tissue at the surgery site; classical piece removal during prosthetic replacement of the knee | University Hospital, Lille, France | Recruiting/April 2021 |
NCT04377880 | Fodzo[175] | Observational study | Osteoporotic patients undergoing total joint arthroplasty | Osteoblastic response to medullary adipocytes of commercial origin analysed by gene expression and correlation with clinical data regarding osteoporosis and microtomography | University Hospital, Lille | May 2021 |
- Citation: Labusca L. Adipose tissue in bone regeneration - stem cell source and beyond. World J Stem Cells 2022; 14(6): 372-392
- URL: https://www.wjgnet.com/1948-0210/full/v14/i6/372.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v14.i6.372