Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology

Figure 1 In vitro radioprotective property of Wharton’s jelly-derived mesenchymal stromal/stem cells and its conditioned medium to murine splenic lymphocytes. Irradiated splenic lymphocytes were either co-cultured with Wharton’s jelly-derived mesenchymal stromal/stem cells (WJ-MSCs) or cultured with conditioned media collected from WJ-MSCs culture for 24 h. Cells were stained with propidium iodide, and cell death was enumerated in lymphocytes. A: Flow cytometry data along with bar graph showed therapeutic radioprotection to lymphocytes when cultured in the presence of WJ-MSCs; B: Flow cytometry data along with bar graph showed radioprotection to lymphocytes when cultured in the presence of conditioned medium. ^aP < 0.05; ^bP < 0.005 compared to radiation control. NM: Non-conditioned media; CM: Conditioned media.