Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes

Figure 2 Menstrual blood-derived endometrial stem cells transplantation significantly improves the morphology and function of the pancreas in streptozotocin-induced type 1 diabetes mice. A: Both Menstrual blood-derived endometrial stem cells Menstrual blood-derived endometrial stem cells (MenSC) and Umbilical cord-derived mesenchymal stem cell (UcMSC) treatments significantly improved the fasting blood glucose levels. ^aP < 0.05 UcMSC treatment vs PBS treatment; ^eP < 0.05 MenSC treatment vs PBS treatment; B and C: UcMSC treatment significantly inhibited the body weight loss and increased the food intake in streptozotocin-induced type 1 diabetes mice. ^aP < 0.05 UcMSC treatment vs PBS treatment; ^eP < 0.05 UcMSC treatment vs MenSC treatment; D: Morphological changes in the pancreases of mice were examined by hematoxylin and eosin staining, and the islets are indicated by green arrows. The images in the left column provide a full view of the pancreas, and the images in the right column are locally magnified; E, F and H: Insulin⁺ (green fluorescence) and CD31⁺ (red fluorescence) cells in the mouse pancreas were detected by immunofluorescence and quantified by IPP software. The images in the top row provide a full view of the pancreases, and the images in the bottom row are locally magnified; G: The serum insulin levels in the mice were determined by ELISA. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. MSC: Mesenchymal stem cell; UcMSC: Umbilical cord-derived MSC; MenSC: Menstrual blood-derived endometrial stem cells.