Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes

Figure 1 Mesenchymal stem cell transplantation promotes pancreatic regeneration and regulates immune homeostasis in streptozotocin-induced type 1 diabetes mice. A: The cytokines examined and representative array images are shown; B and C: The expression levels of vascular endothelial growth factor, Bcl2, BCL-xL, and proliferating cell nuclear antigen in the mouse pancreas were detected by WB, and the relative expression of targeted proteins was quantitated using ImageJ software; D-G: The concentrations of significantly changed cytokines were quantified based on the fluorescence intensities. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. MSC: Mesenchymal stem cell; UcMSC: Umbilical cord-derived MSC; MenSC: Menstrual blood-derived endometrial stem cells; IFN: Interferon; TNF: Tumor necrosis factor; IL: Interleukin; VEGF: Vascular endothelial growth factor; PCNA: Proliferating cell nuclear antigen.