Epigenetic regulation by long noncoding RNAs in osteo-/adipogenic differentiation of mesenchymal stromal cells and degenerative bone diseases

Table 2 Interactions between long noncoding RNAs and epigenetic modifiers during adipogenic differentiation of mesenchymal stromal cells

LncRNAs	Samples	Expression	Epigenetic regulatory mechanisms	Target genes	Effects	Ref.
HOTAIR	hBMSCs	Up	Interacting with DNMTs	NR	Inhibit adipogenic differentiation	Kalwa et al[46]
Plnc1	BMSCs	Up	Reducing the DNA methylation level	Ppar-γ2	Promote adipogenic differentiation	Zhu et al[49]
slincRAD	3T3-L1	Up	Facilitating the recruitment of Dnmt1	Cdkn1a	Promote adipogenic differentiation	Yi et al[50]
ADINR	hASCs	Up	Facilitating the recruitment of MLL3/4 complex (involved in the maintenance of H3K4me3 and the removal of H3K27me3) by binding PA1	C/EBP-α	Promote adipogenic differentiation	Xiao et al[63]
MIR31HG	hASCs	Down	Reducing the enrichment of AcH3 and H3K4me3	FABP4	Inhibit adipogenic differentiation	Huang et al[16]
H19	hBMSCs	Up	facilitating miR-675-mediated repression of HDACs	NR	Inhibit adipogenic differentiation	Huang et al[68]

hBMSCs: Human bone marrow stromal cells; BMSCs: Bone marrow stromal cells; hASCs: Human adipose-derived stromal cells; NR: Not reported.