Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

doi:10.4252/wjsc.v14.i1.76

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Jan 26, 2022 (publication date) through Nov 19, 2024

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Jan 26, 2022; 14(1): 76-91
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.76

Table 3 Regulators of gastric cancer stem cells-related pathway stimuli in gastric cancer stem cells stemless properties and gastric cancer stem cells-targeted therapy

GCSCs pathway	Involved pathway proteins	Therapeutic inhibitor or drug	Ref.
Hedgehog (HH)	PTCH1, SMO, GLI	Vismodegib5E1RobotnikininGANT58GANT61HPI1-4GenisteinResveratrolCyclopamineMir-218SaridegibBMS-833923ErismodegibPF-0449913LY2940680	[27,28,83,84]
Notch/STAT3	Notch ligands (DLL), Notch receptors, JAK, ERK, STAT3	NapabucasinDemclzumab (anti-DLL4)TarextumabBBI-608	[28,76,85,86]
NANOG	NANOG, STAT3, Kinases	NapabucasinBBI-608BB1-503	[28,73,75,85]
Wnt/β-catenin	Wnt, β-catenin, LRP/FZD	Napabucasin BBI-608Vantictumab (anti-FZD)LGK974Foxy-5	[28,77,78,85,86]

GCSCs: Gastric cancer stem cells; HH: Hedgehog; NANOG: Nanog homeobox; STAT3: Signal transducer and activator of transcription 3; GLI: Glioma-associated oncogene; SMO: Smoothened; PTCH1: Patched homolog 1; ERK: Extracellular-signal-regulated kinase; JAK: Janus kinase; Wnt: Wingless/int1; LRP: Lipoprotein receptor-related proteins/low density lipoprotein receptor-related proteins; FZD: Frizzled receptors; DLL: Notch ligands.

Citation: Hsieh HL, Yu MC, Cheng LC, Yeh TS, Tsai MM. Molecular mechanism of therapeutic approaches for human gastric cancer stem cells. World J Stem Cells 2022; 14(1): 76-91
URL: https://www.wjgnet.com/1948-0210/full/v14/i1/76.htm
DOI: https://dx.doi.org/10.4252/wjsc.v14.i1.76