Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

doi:10.4252/wjsc.v14.i1.76

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Jan 26, 2022 (publication date) through Dec 30, 2024

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Jan 26, 2022; 14(1): 76-91
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.76

Table 2 Potential gastric cancer stem cells intracellular markers

Intracellular markers	Function	Physiological significance					Involved signaling pathways	Therapeutic targets	Prognostic marker of GC	Ref.
Intracellular markers	Function	Tumorigenicity/GCSC generation	Spheroid formation	Chemo-resistance	Radio-resistance	EMT/metastasis	Involved signaling pathways	Therapeutic targets	Prognostic marker of GC	Ref.
DOCK6	Dock-C subfamily guanine nucleotide exchanger	●	●	●	●	●	Wnt/β-catenin pathway	DOCK6	●	[50]
Mist1	Transcriptional factor	●	●	●	ND	●	Wnt/β-catenin pathway	Mist1	●	[51]
MSI-1	RNA-binding protein	●	●	●	ND	●	EGFR pathway	MSI-1	●	[48]
NANOG	Transcription factor	●	●	●	ND	●	Wnt/β-catenin pathwayJAK-STAT pathway	NANOG	●	[23,52]
Oct3/4	Octamer-binding transcription factor 3/4	●	●	●	ND	●	Wnt/β-catenin pathwayJAK-STAT pathway	Oct3/4	●	[23,53]
SOX2	Sex determining region Y-box 2	●	●	●	ND	●	Wnt/β-catenin pathwayJAK-STAT pathway	SOX2MiR-134all-trans retinoic acid	●	[52-57]

●: Determined; ND: Not determined; DOCK6: Dedicator of cytokinesis 6; Mist1: Muscle, intestine and stomach expression 1; MSI-1: Musashi RNA binding protein 1; GCSCs: Gastric cancer stem cells; GC: Gastric cancer; EMT: Epithelial–mesenchymal transition; NANOG: nanog homeobox; Oct3/4: Octamer-binding transcription factor 3/4; SOX2: Sex determining region Y-box 2; MAPK: Mitogen-activated protein kinase; ERK: Extracellular-signal-regulated kinase; JAK: Janus kinase; STAT3: Signal transducer and activator of transcription 3; EGFR: Epidermal growth factor receptor; miRNA: MicroRNA.

Citation: Hsieh HL, Yu MC, Cheng LC, Yeh TS, Tsai MM. Molecular mechanism of therapeutic approaches for human gastric cancer stem cells. World J Stem Cells 2022; 14(1): 76-91
URL: https://www.wjgnet.com/1948-0210/full/v14/i1/76.htm
DOI: https://dx.doi.org/10.4252/wjsc.v14.i1.76