Cardiac stem cells: Current knowledge and future prospects

doi:10.4252/wjsc.v14.i1.1

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Jan 26, 2022 (publication date) through Jul 21, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2022; 14(1): 1-40
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.1

Table 3 Ongoing and future expected clinical trials

Study name, NCT number	Year of study start	Study phase	Cardiovascular disease	Number of patients	Type of cardiac cells	Route of delivery
Regress-HFpEF, 02941705	2017	II	Symptomatic hypertensive heart disease induced HFpEF	40	Allogeneic CDCs	IC
APOLLON trial, 02781922	2016	III	HLHS	40	Autologous CSCs	IC
CHILD, 03406884	2019	I	HLHS	32	Autologous c-KIT⁺ cells	IM
ALPHA, 03145298	2017	I	PAH	26	Allogeneic CDC	IV
TAC-HFT-II, 02503280	2025	I/II	IHF	0 enrollment until now	Autologous combination of MSCs and CSCs	Trans endocardial Injection

CSC: Cardiac stem cell; HFpEF: Heart failure with preserved ejection fraction; HLHS: Hypoplastic left heart syndrome; IC: Intracardiac; IHF: Ischemic heart failure; IM: Intramyocardial; IV: Intravenous; NCT: National clinical trial; PAH: Pulmonary atrial hypertension.

Citation: Mehanna RA, Essawy MM, Barkat MA, Awaad AK, Thabet EH, Hamed HA, Elkafrawy H, Khalil NA, Sallam A, Kholief MA, Ibrahim SS, Mourad GM. Cardiac stem cells: Current knowledge and future prospects. World J Stem Cells 2022; 14(1): 1-40
URL: https://www.wjgnet.com/1948-0210/full/v14/i1/1.htm
DOI: https://dx.doi.org/10.4252/wjsc.v14.i1.1