Inter-regulatory role of microRNAs in interaction between viruses and stem cells

Figure 1 MicroRNA biogenesis begins with the generation of the primary microRNA transcript. The microprocessor complex, comprised of Drosha and DiGeorge syndrome critical region 8, cleaves the primary microRNA (miRNA) to produce the precursor miRNA. The precursor miRNA is exported to the cytoplasm in an exportin-5 dependent manner and processed to produce the mature miRNA duplex. Finally, mature miRNA duplex is loaded into the Argonaute family of proteins to form a miRNA-induced silencing complex. miRNA: MicroRNA; Pri-miRNA: Primary microRNA; Pre-miRNA: Precursor microRNA; miRISC: MicroRNA within the RNA-induced silencing complex; DGCR8: DiGeorge syndrome critical region 8; Ago: Argonaute; TRBP: Transactivation response element RNA-binding protein.