Effects of radiation and chemotherapy on adipose stem cells: Implications for use in fat grafting in cancer patients

Table 1 Availability of adipose-derived stem cells in patients receiving chemotherapy

Patient population	ASC yield (million/gram of fat)	Growth rates (dT) (h)	Adipogenic differentiation
Received NAC (n = 11)
Tumor side	0.69 ± 0.20	37.44	+
Normal side	0.99 ± 0.29	36.48	+
	P = NS vs no received NAC	P = NS
No receiving NAC (n = 10)
Tumor side	0.52 ± 0.10	33.84	+
Normal side	0.71 ± 0.17	31.20	+
	P = NS vs normal side	P = NS

The number of adipose-derived stem cells (ASCs) harvested and growth rates did not appear to be significantly affected in patients post-chemotherapy; these cells appeared to retain the capacity to acquire adipocyte traits similar to the ASCs from patients not receiving chemotherapy. ASC: Adipose-derived stem cell; NAC: neoadjuvant chemotherapy; NS: Not significant.