Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia

Table 3 The key parameter of clinical trials using transplantation of mesenchymal stem cells in treating ischemic stroke

Ref.	Country	Design	Type	Route	MSCs source	Sample size (cases)		Dose	How long	Follow-up
					Auto or allo	MSCs	Control	(Mean)	(Mean)	(Mean)
Savitz et al[137], 2011	America	Non-RCT	Acute	IV	BM/Auto	10	NA	100 × 106	1-3 d	0.5 yr
Lee et al[138], 2010	South Korea	RCT	Acute	IV	PIC/Auto	16	36	50 × 106	1 wk	5 yr
Bhasin et al[151], 2011	India	Non-RCT	Chronic	IV	BM/Auto	4	5	50-60 × 106	8 wk	24 wk
Bhasin et al[139], 2012	India	Non-RCT	Chronic	IV	PIC/Auto	12	12	50-60 × 106	3-24 mo	0.5 yr
Bhasin et al[140], 2016	India	Non-RCT	Chronic	IV	PIC/Auto	20	20	50-60 × 106	3-24 mo	0.5 yr
Chen et al[141], 2014	China	RCT	Chronic	Stereotactic	PB/Auto	15	15	3-8 × 106	0.5-5 yr	1 yr
Jiang et al[149], 2013	China	Non-RCT	NA	Catheterization	UC/Allo	3	NA	20 × 106	11-22 d	0.5 yr
Laskowitz et al[14], 2018	America	RCT	Acute	IV	UC/Allo	10	10	3.34 × 106	3-9 d	1 yr
Levy et al[142], 2019	America	Non-RCT	Chronic	IV	NA/Allo	15 and 20	NA	NA	NA	1 yr
Moniche et al[143], 2012	Spain	RCT	Subacute	IA	PIC/Auto	10	10	159 × 106	5-9 d	0.5 yr
Prasad et al[144], 2014	India	RCT	Subacute	IV	PIC/Auto	60	60	280.5 × 106	1-4 mo	0.5 yr
Suárez-Monteagudo et al[150], 2009	Cuba	Non-RCT	NA	IV	BM/Auto	3	NA	NA	NA	3 M
Vahidy et al[145], 2019	America	RCT	Acute	IV	BM/Auto	25	30	NA	1-3 d	2 yr
Zhang et al[146], 2019	China	Non-RCT	NA	Stereotactic	FSC/Allo	9	NA	NA	494 d	2 yr
Díez-Tejedor et al[148], 2014	Spain	RCT	Acute	IV	Adipose/Allo	20	20	NA	0.5 mo	2 yr
Feng et al[147], 2014	China	NA	Subacute	Stereotactic	UC/Allo	50	50	100 × 106	0.5-1 mo	0.25 yr
Jaillard et al[153], 2020	France	RCT	Subacute	IV	BM/Allo	16	15	100-300 × 106	3 wk	24 mo
De Keyser[152], 2005	South Korea	Non-RCT	Acute	IV	BM/Allo	5	25	50 × 106	4-9 wk	12 mo

NA: Not available; MSCs: Mesenchymal stem cells; Auto: Autologous; Allo: Allogenicr; PIC: Posterior iliac crest; IV: Intravenous; IA: Intraarterial; RCT: Randomized controlled trial; UC: Umbilical cord; BM: Bone marrow; FSC: Fetal spinal cord; PB: Peripheral blood.