Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Figure 2 Clinical (Knee injury and osteoarthritis outcome score and Knee society score, n = 34) and imaging (magnetic resonance imaging, n = 30) outcomes from patients with knee Osteoarthritis treated with bone marrow mononuclear cells over 12 mo post-treatment[102]. A and B: Significant improvements (P < 0.05) were observed for Knee injury and osteoarthritis outcome score’ (A) and Knee Society Score (B) scores during the 12-mo follow-up period and most were sustained over time; C: Changes in bone marrow edema, cartilage and synovitis detected by magnetic resonance imaging 6 mo after treatment with bone marrow mononuclear cells. Citation: Goncars V, Kalnberzs K, Jakobsons E, Enģele I, Briede I, Blums K, Erglis K, Erglis M, Patetko L, Muiznieks I, Erglis A. Treatment of Knee Osteoarthritis with Bone Marrow–Derived Mononuclear Cell Injection: 12-Month Follow-up. Cartilage 2019; 10 (1): 26-35. Copyright © The Author(s) 2018. Published by SAGE Publications. KOOS: Knee injury and osteoarthritis outcome Score; KSS: Knee society score; QoL: Quality of life; ADL: Activities of daily living; BME: Bone marrow edema.