Review
Copyright ©The Author(s) 2021.
World J Stem Cells. Jul 26, 2021; 13(7): 795-824
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.795
Figure 2
Figure 2 The complexity of hepatocellular carcinoma and its microenvironment. A: Hepatocellular carcinoma and its tumor microenvironment are composed of various cell populations, including differentiated cancer cells, cancer stem cells, cancer associated fibroblasts, immune and endothelial cells; B: Programmed death-1 and programmed death ligand 1 interaction and inhibition by neutralizing antibodies in tumor growth. PD-1: Programmed death-1; PD-L1: Programmed death ligand 1; CSC: Cancer stem cells; CAF: Cancer associated fibroblast; ECM: Extracellular matrix; NK: Natural killer.