Stem cell therapies in tendon-bone healing

doi:10.4252/wjsc.v13.i7.753

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jul 26, 2021; 13(7): 753-775
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.753

Table 3 Summary of pre-clinical studies using gene-modified bone marrow mesenchymal stem cells

Ref.	Animal/model	Cell/cell number	Transfected gene	Method of delivery	Control	Timeline	Outcome measurement
Gulotta et al[72], 2010	Rat/Unilateral detachment and repair of the supraspinatus tendon	BMSCs/× 10⁶	MT1-MMP	BMSCs were pelleted down and mixed with fibrin sealant for implantation	Rotator cuff repair with normal BMSCs	2 and 4 wk	Histology, biomechanics
Gulotta et al[76], 2011	Rat/Unilateral detachment and repair of the supraspinatus tendon	BMSCs/× 10⁶	Scx	BMSCs were pelleted down and mixed with fibrin sealant for implantation	Rotator cuff repair with normal BMSCs	2 and 4 wk	Histology, biomechanics
Gulotta et al[77], 2011	Rat/Unilateral detachment and repair of the supraspinatus tendon	BMSCs/× 10⁶	BMP-13	BMSCs were pelleted down and mixed with fibrin sealant for implantation	Rotator cuff repair with normal BMSCs	2 and 4 wk	Histology, biomechanics
Dong et al[78], 2012	Rabbit/Unilateral ACL reconstructions using gastrocnemius tendon autografts	BMSCs/× 10⁷	BMP-2	Grafts were coated with BMSCs in a fibrin glue carrier	ACL reconstruction without BMSCs	4 and 8 wk	Histology, biomechanics
Wang et al[79], 2017	Rabbit/Unilateral ACL reconstructions using flexor digitorum longus tendon autografts	BMSCs/-	TGF-β	BMSCs were injected into the bone tunnel and graft tendon cavity	ACL reconstruction with normal BMSCs	6 and 12 wk	Histology, immunohistochemistry, biomechanics, 3D-CT
Wang et al[80], 2018	Rat/Bilateral detachment and repair of the supraspinatus tendon	BMSCs/1.6 × 10⁷	PDGF-B	BMSCs with fibrin glue implanted into the defects	Rotator cuff repair with irrelevant plasmid-transfected BMSCs	4 and 8 wk	Histology, immunohistochemistry, biomechanics

BMSC: Bone marrow mesenchymal stem cell; MT1-MMP: Membrane type 1 matrix metalloproteinase; Scx: Scleraxis; BMP-13: Bone morphogenetic protein-13; BMP-2: Bone morphogenetic protein-2; TGF-β: Transforming growth factor-beta; PDGF-B: Platelet-derived growth factor subunit B.

Citation: Xu Y, Zhang WX, Wang LN, Ming YQ, Li YL, Ni GX. Stem cell therapies in tendon-bone healing. World J Stem Cells 2021; 13(7): 753-775
URL: https://www.wjgnet.com/1948-0210/full/v13/i7/753.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i7.753