Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells

doi:10.4252/wjsc.v13.i6.542

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jun 26, 2021; 13(6): 542-567
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.542

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Figure 2 Epigenetic regulation of autophagy in cancer cells and cancer stem cells. Autophagy in cancer cells and cancer stem cells is tightly regulated by the dynamic interplay of different epigenetic modifications, such as DNA methylation, histone remodeling and non-coding RNAs. Pathological epigenetic changes in cancer can directly regulate autophagy by targeting the core genes or indirectly through the regulatory elements. ER: Endoplasmic reticulum; M: Methyl group; TF: Transcription factor.

Citation: Mandhair HK, Novak U, Radpour R. Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells. World J Stem Cells 2021; 13(6): 542-567
URL: https://www.wjgnet.com/1948-0210/full/v13/i6/542.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i6.542