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©The Author(s) 2021.
World J Stem Cells. Jun 26, 2021; 13(6): 632-644
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.632
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.632
Table 2 Summary of the main results obtained in mesenchymal stem cell-based experiments for glaucoma
MSC source | Treatment | Results | Ref. |
Rat BMSCs | In vitro co-cultures of BMSCs with pigmented cells from ciliary margin | Enhanced expression of cone-rod homeobox, at both mRNA and protein level | Li et al[43], 2017 |
Mouse BMSCs | BMSC injection into the ocular anterior chamber of a laser-induced rat model | Decreased intraocular pressure likely due to MSC paracrine activity | Manuguerra-Gagné et al[44], 2013 |
Rat BMSCs | BMSC injection into the ocular anterior chamber of a rat model obtained by cauterization of episcleral veins | Reduced intraocular pressure, associated to MSC engrafting to the ciliary processes and to the trabecular meshwork | Roubeix et al[45], 2015 |
BMSC-conditioned medium treatment of TGF-β2-induced fibrotic human trabecular meshwork cell cultures | Improved survival of trabecular meshwork cells, by activation of anti-apoptotic signaling pathway Akt | ||
Rat BMSCs | Intravitreal or intravenous administration of labeled BMSCs in a laser-induced ocular hypertension rat model | Local but not systemic BMSC administration improved retinal ganglion cell survival. Transplanted BMSCs were preferentially located in a perivascular position | Johnson et al[47], 2010 |
Rat/humanBMSCs | Co-cultures of retinal explants with rat and human BMSCs, or rat and human fibroblasts | BMSCs but not fibroblasts improved retinal ganglion cell survival. An increased density of cells expressing islet-1 and NeuN was found in retinal ganglion cell layer | Johnson et al[48], 2014 |
Exposure of retinal explant cultures to conditioned media from BMSCs or fibroblast | Moderate improvements were observed only for BMSC conditioned medium treatment | ||
Human BMSCs | Intravitreal injections of extracellular vesicles obtained from BMSCs of fibroblasts in two rat models of glaucoma | BMSC extracellular vesicles more efficiently reduced retinal ganglion cell apoptosis | Mead et al[38], 2018 |
Engineered mouse BMSCs | Indirect co-cultures of BMSCs with retinal ganglion cells in a transwell system | BMSCs enhanced anti-apoptotic effects on retinal ganglion cells by upregulation of stanniocalcin-1. Improved effects were obtained by miRNA-21-overexpressing BMSCs | Su et al[49], 2017 |
Autologous BMSCs | Clinical trial carried out by intravitreal injection of autologous BMSCs in patients with advanced stage of glaucoma | No significant improvements were reported | Vilela et al[50], 2021 |
- Citation: Mannino G, Russo C, Longo A, Anfuso CD, Lupo G, Lo Furno D, Giuffrida R, Giurdanella G. Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases. World J Stem Cells 2021; 13(6): 632-644
- URL: https://www.wjgnet.com/1948-0210/full/v13/i6/632.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v13.i6.632