Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

Figure 2 Changes in the hindlimb score in the experimental groups up to 12 wk after directly reprogrammed neural precursor cell transplantation or vehicle injection. A: Hindlimb scores of individual animals; B: Box plots of the parameters in the lesion control (LC) group and neural progenitor cell (NPC) groups (the median, the minimum, and maximum values and the first and third quartiles). The hindlimb scores of the LC group did not change over time. However, the hindlimb scores in the NPC group significantly increased over time and were statistically significant at 4, 8, and 12 wk post transplantation when compared to the pretransplantation time point (P < 0.01). Differences between the LC and NPC groups are significant from the 4^th wk (P < 0.01, as estimated using the mixed linear model).