Low complexity domains, condensates, and stem cell pluripotency

Figure 3 Activation of the wingless-related integration site, transforming growth factor beta, and Janus kinase/signal transducers and activators of transcription signaling pathways leads to nuclear translocation of their respective terminal signaling effectors: β-catenin, SMAD family member 3, and signal transducers and activators of transcription 3. These low complexity domain (LCD)-containing transcription factors bind their respective signal-responsive elements in pluripotency gene promoters and form LCD-mediated condensates with Mediator to modulate ESC-specific transcriptional activation in a signal-dependent manner. JAK: Janus kinase; STAT: Signal transducers and activators of transcription; SMAD3: SMAD family member 3; TGF-β: Transforming growth factor beta; Wnt: Wingless-related integration site.