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Copyright ©The Author(s) 2021.
World J Stem Cells. May 26, 2021; 13(5): 439-451
Published online May 26, 2021. doi: 10.4252/wjsc.v13.i5.439
Table 3 Advantages and disadvantages of stem cells in clinical trials

Advantages
Disadvantages
ESCs
High differentiation capability which can recapitulate appropriate cell-intrinsic phenotypesEthical dilemma
Grow up in the laboratory from a single cell for later transplantationTumorigenesis risk
MSCs
Immunomodulatory propertiesA narrower spectrum of differentiation
Widespread availability and accessibilityHigh expression of ACE2 receptor
Limited ethical concernsExpression of MHC I and II