Review
Copyright ©The Author(s) 2021.
World J Stem Cells. May 26, 2021; 13(5): 416-438
Published online May 26, 2021. doi: 10.4252/wjsc.v13.i5.416
Table 1 Low complexity domain-containing proteins in transcriptional activation and repression in embryonic stem cells
Ref.LCD-FactorsLCD-domainNature of LCDExperimentally confirmed
Modifications
In vitro
In vivo
Boija et al[46]MED1C-terminusPolarYesYes1NA
Boija et al[46] Brehm et al[47]OCT4N- and C-terminal domainsAcidic amino acids (electrostatic)YesYes1Phosphorylation
Boija et al[46] Xue et al[48] SOX2N-terminusNAYesNANA
Boija et al[46] Metallo et al[49] c-MYCEntire polypeptideNAYesNANA
Boija et al[46] Jenkins et al[50]; Oldfield et al[51]p53N- and C-terminal domainsAcidic amino acids (N-terminus)YesNAPhosphorylation
Boija et al[46] Xue et al[48] NANOGN- and C-terminal domainsNAYesNANA
Boija et al[46]ERNANAYesNANA
Choi et al[30]ABCF1N-terminusNAYesYes2NA
Boehning et al[52]RNA Pol IIC-terminusHydrophobic and electrostaticYesYes1Phosphorylation
Lau et al[53]HP1αN-terminusAcidic amino acidsYesYes1Phosphorylation
Plys et al[54]CBX2Entire polypeptidePositively chargedYesYes2Phosphorylation