Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research

Table 1 Main genes associated with inherited cardiomyopathies

Condition	Genotype	Ref.
HCM1	MYBPC3, MYH7, TNNT2, TNNI3, TPM1, ACTC1, MYL2, MYL3	[13]
DCM	TTN, LMNA, MYH7, TNNT2, BAG3, RBM20, TNNC1, TNNI3, TPM1, SCN5A, PLN	[14,15]
LVNC	Overlap with HCM and DCM	[14,15]
ACM	DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, PLN, RYR2, SCN5A, TMEM43, TTN	[14,15]
RCM	TTR, TNNI3, DES. Overlap with HCM and DCM	[14,15]

¹Only genes having definitive evidence for hypertrophic cardiomyopathy have been depicted. ACM: Arrhythmogenic cardiomyopathy; DCM: Dilated cardiomyopathy; HCM: Hypertrophic cardiomyopathy; LVNC: Left ventricular noncompaction; RCM: Restrictive cardiomyopathy.