Review
Copyright ©The Author(s) 2021.
World J Stem Cells. Apr 26, 2021; 13(4): 236-259
Published online Apr 26, 2021. doi: 10.4252/wjsc.v13.i4.236
Table 1 Summary of landmark human clinical trials
Cell type
Clinical trial
Sample size
Results
Ref.
ESCsESCORT6Improvement in NYHA functional class, 6 min test and heart wall motion[32]
iPSCsCyranoski, 201810Trial results pending[36]
HEAL-CHF5Trial results pending[36]
CSCsCADUCEUS31Improvements in scar size, regional contractility and heart mass; no differences in EDV, ESV and LVEF between groups[42]
BMMNCsPerin et al[44], 200321Improvements in LVEF, perfusion and contractility; Reductions in ESV[44]
TOPCARE-CHD121Improvements in global cardiac function and contractility, decreased BNP and mortality[45]
STAR-heart;191Improvements in LVEF, NYHA functional class and long-term mortality; Decreased LV preload, ESV and infarct area[46]
FOCUS-CCTRN92No improvements in LVEF, maximal O2 consumption and infarct size[47]
BMMNCs and autologous MSCsTAC-HFT65 Decreased infarct size and improvements in 6 min walk test and regional function of the heart in MSC group only[49]
CD133(+)CARDIO3360No improvements in LV function or clinical symptoms[50]
BMDSCsSystematic review and meta-analysis1907Low-quality evidence that BMDSCs reduce mortality, improves LVEF and improves NYHA functional class[51]
Autologous MSCsMSC-HF60Improvements in LVEF, stroke volume and myocardial mass[54]
Autologous and allogeneic MSCsPOSEIDON30Improvements in LV functions with reductions in adverse remodeling, infarct size[55]
POSEIDON-DCM37Greater improvements seen in allogeneic MSCs regarding functional capacity, quality of life, EF, 6 min walk test, and the Minnesota Living with HF questionnaire[56]
CardiopoieticC-CURE36Improvements in LVEF, quality of life and decreased LVESV[57]
CHART-1 351Decreased LVESV and LVEDV[58]
Umbilical MSCsRIMECARD30Improvements in LVEF but no improvements in LVESV or LVEDV[60]
Zhao et al[61], 201559No improvements in LVEF but some improvements in the 6 min walk test, mortality rate and NT-pro brain natriuretic peptide levels[61]
MPCsDREAM-HF-1566Trial results pending[64]
MSCsSystematic review and meta-analysis29 studiesImprovements in LVEF, LVESV, NYHA functional class, quality of life and exercise capacity[65]
Systematic review and meta-analysis12 studiesNo significant improvements in LVEF. Improvements in quality of life and the 6 min walk test[52}
SMsMAGIC120 with 7 patients on f/uNo improvements in LVEF or global heart function[68,69]
MARVEL23No improvements in LV function; Moderate improvements in 6 min walk test[71]