Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway

Figure 7 X-ray and magnetic resonance imaging evaluation in intervertebral disc degeneration animal models. A: The X-ray in different groups at 0 wk and 4 wk after puncturing; B: Quantitative analysis of the disc height index in different groups; C: The magnetic resonance imaging results of different groups at 0 wk and 4 wk after puncture; D: Quantitative analysis of Pfirrmann grades in different groups. All data are expressed as the mean ± SD. ^aP < 0.05, ^bP < 0.01 compared with control group; ^cP < 0.05, ^dP < 0.01 compared with H₂O₂ group; ^eP < 0.05, ^fP < 0.01 compared with UA group. DHI: Disc height index; MRI: Magnetic resonance imaging; IDD: Intervertebral disc degeneration; UA: Urolithin A.