Copyright
©The Author(s) 2021.
World J Stem Cells. Dec 26, 2021; 13(12): 1881-1904
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1881
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1881
Table 2 Variation in properties of different sources of stem cell types
Properties | MSCs | ESCs | iPSCs |
Sources | Perinatal and adult tissues | Embryo at blastocyst stage | Genetically reprogrammed specialized cells |
Plasticity | Multipotent | Pluripotent | Pluripotent |
Teratoma formation | No | Yes | Yes |
Growth | Limited | High | High |
Ethical concerns | No | Yes | No |
Immune rejection | No | Yes | No |
Cell transplantation | Autologous and allogenic | Allogenic | Autologous |
Clinical trials in human patients | Ongoing | Limited | In vitro/in vivo only |
Use in genetic disorder | Deficient (Carry mutated gene) | Superior | Deficient (Carry mutated gene) |
Ease of isolation | Yes | No | No |
- Citation: Ekram S, Khalid S, Salim A, Khan I. Regulating the fate of stem cells for regenerating the intervertebral disc degeneration. World J Stem Cells 2021; 13(12): 1881-1904
- URL: https://www.wjgnet.com/1948-0210/full/v13/i12/1881.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v13.i12.1881