Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

Table 2 Interleukin-17 inhibits osteogenesis: Summary of the main literature data

Cells	Differentiation effects, differentiation markers, signaling, and transcription factors	Ref.
Human periodontal ligament stem cells	Reduces mineralization and ALP activity, and OC; Activates ERK1/2 and JNK	Đorđević et al[137]
Human periodontal ligament stem cells	Reduces ALP activity, and RUNX2, SP7, and OCN expression; Inhibits ERK1/2, p38, and JNK signaling	Jian et al[138]
Murine calvaria progenitor osteoblastic cells	Reduces ALP, mineralization, and nodule formation	Kim et al[139]
Murine-derived BM MSC	IκB kinase-NF-κB dependent catenin degradation	Chang et al[141]
Human bone mesenchymal stem cells	Reduces mineralization; Inhibits RUNX2, ALP, and OPN expression; Wnt inhibition by sFRP1 increased expression	Wang et al[142]
Murine calvaria progenitor osteoblastic cells	Reduces mineralization and ALP activity; Inhibits OC expression; Inhibits Wnt signaling by increasing sFRP1 and suppressing sFRP3 expression	Shaw et al[143]
Murine calvaria progenitor osteoblastic cells	Increases miR-214 and RANKL expression	Liu et al[150]

BM: Bone marrow; MSC: Mesenchymal stem/stromal cell; NF-κB: Nuclear factor-κB; ALP: Alkaline phosphatase; OPN: Osteopontin; OC: Osteocalcin.