Current knowledge on the multiform reconstitution of intestinal stem cell niche

doi:10.4252/wjsc.v13.i10.1564

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Oct 26, 2021 (publication date) through Jul 28, 2024

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Oct 26, 2021; 13(10): 1564-1579
Published online Oct 26, 2021. doi: 10.4252/wjsc.v13.i10.1564

Table 1 Organoid culture conditions for multiform reconstitution of the intestinal stem cell niche

	Media for canonical organoid culture	Media for organoids on 2D monolayer or 3D scaffold
Human small intestinal organoids	Wnt, R-spondin, EGF, IGF-1, FGF, Noggin, TGF-βi, p38i, gastrin[43]	Noggin, EGF, R-spondin, GSK-3i, ROCKi[44]
Human colon intestinal organoids	Wnt, R-spondin, EGF, Noggin, TGF-βi, p38i, gastrin[43]	Wnt, R-spondin, EGF, Noggin, EGF, TGF-βi, p38i, gastrin[45]
Mouse small intestinal organoid	R-spondin, EGF, Noggin[24]	Noggin, EGF, R-spondin, ROCKi[46]
Mouse colon intestinal organoid	Wnt, R-spondin, EGF, Noggin[24]	Wnt, R-spondin, EGF, Noggin, TGF-βi[47]

TGF-βi: Transforming growth factor-β inhibitor; p38i: p38 inhibitor; GSK-3: Downstream of Lrp5 receptor, transduce nuclear translocation when suppressed; EGF: Epidermal growth factor; IGF-1: insulin-like growth factor 1; FGF: Fibroblast growth factor.

Citation: Xu ZY, Huang JJ, Liu Y, Zhao Y, Wu XW, Ren JA. Current knowledge on the multiform reconstitution of intestinal stem cell niche. World J Stem Cells 2021; 13(10): 1564-1579
URL: https://www.wjgnet.com/1948-0210/full/v13/i10/1564.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i10.1564