Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update

Table 2 Nutritional support therapy recommendations in hematopoietic stem cell transplantation patients by phases[9]

	Oral/EN			PN (Digestive intolerance)
	Severe malnutrition
	No		Yes	No	Yes
Before transplantation	Normal protein: Low microbial diet		High protein EN	Minimal EN, normal protein PN	Minimal EN, high protein PN
Conditioning regimen (–7 to 0 d)1	High protein: Low microbial diet		High protein EN, supplements	Minimal EN, normal protein PN, glutamine	Minimal EN, high protein PN, glutamine
After Transplantation
Phase I2 (0–30 d)	Low microbial diet, EN	High protein EN, glutamine		Minimal EN, normal protein PN, glutamine	Minimal EN, high protein PN, glutamine
Phase II3 (30–90 d)	Decrease EN, bland diet	Normal protein EN, supplements		EN 50% + PN 50%, normal protein	EN 50% + PN 50%, high protein
Phase III4 (> 90 d)	Standard, bland diet	Standard diet, supplements		EN 100% or normal protein bland diet	EN 100% or high protein bland diet

In some sources, durations are given as follows:

¹-10 to 0 d.

²0 to +21 d.

³+21 to +100 d.

⁴> 90 d. EN: Enteral Nutrition; PN: Parenteral Nutrition.