Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes

doi:10.4252/wjsc.v12.i8.761

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2020; 12(8): 761-775
Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.761

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Figure 1 Stepwise in vitro differentiation of pancreatic cells from human embryonic stem cells. Stage-specific markers, regulating pathways, recombinant proteins, and small molecules added at different stages are listed. +: Positive regulation; -: Negative regulation; IDE: Induction of definitive endoderm; Shh: Sonic hedgehog; KGF: Keratinocyte growth factor; RA: Retinoic acid; PKC: Protein kinase C; ILV: Indolactum V; HGF: Hepatocyte growth factor; RSV: Resveratrol.

Citation: Chen ACH, Lee KF, Yeung WSB, Lee YL. Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes. World J Stem Cells 2020; 12(8): 761-775
URL: https://www.wjgnet.com/1948-0210/full/v12/i8/761.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i8.761