Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Table 3 Clinical trials associated with the use of mesenchymal stromal cells in coronavirus disease-19

NCT number	Title	Status	MSCs origin	Route of infusion
NCT04252118	Mesenchymal stem cell treatment for pneumonia patients infected with COVID-19	Recruiting	Not specified	Intravenously
NCT04313322	Treatment of COVID-19 patients using Wharton's Jelly-mesenchymal stem cells	Recruiting	Wharton’s Jelly MSCs	Intravenously
NCT04336254	Safety and efficacy study of allogeneic human dental pulp mesenchymal stem cells to treat severe COVID-19 patients	Recruiting	Allogeneic human dental pulp stem cells	Intravenously
NCT04288102	Treatment with mesenchymal stem cells for severe COVID-19	Recruiting	Not specified	Intravenously
NCT04346368	Bone marrow-derived mesenchymal stem cell treatment for severe patients with COVID-19	Not yet recruiting	BM-MSCs	Intravenously
NCT04366323	Clinical trial to assess the safety and efficacy of intravenous administration of allogeneic adult mesenchymal stem cells of expanded adipose tissue in patients with severe pneumonia due to COVID-19	Not yet recruiting	Allogeneic and expanded adipose tissue-derived MSCs	Intravenously
NCT04276987	A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe novel coronavirus pneumonia	Not yet recruiting	MSCs-derived exosomes	5 times aerosol inhalation of MSCs derived exosomes
NCT04269525	Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) treatment for the 2019-novel coronavirus (nCOV) pneumonia	Recruiting	UC-MSCs	Intravenously
NCT04348461	Battle against COVID-19 using mesenchymal stromal cells	Not yet recruiting	Allogeneic and expanded adipose tissue-derived MSCs	Intravenously
NCT03042143	Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) (COVID-19)	Recruiting	Human umbilical cord derived CD362 enriched MSCs	Intravenously
NCT04333368	Cell therapy using umbilical cord-derived mesenchymal stromal cells in SARS-CoV-2-related ARDS	Recruiting	Umbilical cord Wharton's jelly-derived human	Intravenously
NCT04352803	Adipose mesenchymal cells for abatement of SARS-CoV-2 respiratory compromise in COVID-19 disease	Not yet recruiting	Autologous adipose MSC's	Intravenously

COVID-19: Coronavirus disease-19; MSCs: Mesenchymal stromal cells; SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2; ARDS: Acute respiratory distress syndrome; UC-MSCs: Umbilical cord-derived mesenchymal stem cells; BM-MSCs: Bone marrow-derived mesenchymal stem cells.