High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration

Table 4 Effect of age and lesion size on clinical outcomes

	Age (n = 125)				Lesion size (n = 125)
	β	t	R2	P value1	β	t	R2	P value1
IKDC
Pre-op	-0.128	-1.429	0.016	0.156	-0.148	-1.661	0.022	0.099
1 yr	-0.095	-1.053	0.009	0.294	-0.025	-0.282	0.001	0.779
2 yr	-0.053	-0.593	0.003	0.554	-0.120	-1.339	0.014	0.183
3 yr	0.049	0.549	0.002	0.584	0.024	0.266	0.001	0.791
WOMAC
Pre-op	0.327	3.831	0.107	< 0.001	0.305	3.550	0.093	0.001
1 yr	0.173	1.945	0.030	0.054	0.040	0.440	0.002	0.661
2 yr	-0.005	-0.055	< 0.001	0.956	0.052	0.575	0.003	0.566
3 yr	-0.048	-0.532	0.002	0.595	-0.064	-0.716	0.004	0.475
VAS
Pre-op	0.115	1.286	0.013	0.201	0.335	3.943	0.112	< 0.001
1 yr	0.114	1.278	0.013	0.204	0.113	1.266	0.013	0.208
2 yr	0.001	0.013	<0.001	0.989	0.112	1.249	0.013	0.214
3 yr	-0.047	-0.519	0.002	0.605	0.164	1.842	0.027	0.068

Boldface indicates statistical significance (P < 0.05).

¹Simple regression analysis. Pre-op: Preoperative; IKDC: International Knee Documentation Committee; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; VAS: Visual analog scales.