Insights of stem cell-based endogenous repair of intervertebral disc degeneration

Table 1 Expression of stem/progenitor immunophenotypes and genes of the intervertebral disc

Ref.	Type of stem cells	Expression of stem cell/progenitor immunophenotypes and genes
Human
Liu et al[35], 2016	NP-MSCs	CD73+, CD90+, CD105+, Oct4+, Nanog+, Jagged+ and Notch1+, CD34-, CD45-,HLA-DR-
Li et al[36], 2017	NP-SCs	GD2+, Tie2+
Li et al[37], 2018	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-, HLA-DR-
Jia et al[38], 2017	D-NP-MSCs/ND-NP-MSCs	CD73+, CD90+, CD105+, Oct4+ and Nanog+, CD34-, CD45-, HLA-DR-
Wu et al[40], 2017	NP-SCs/NPPCs	CD29+, CD44+, CD 73+, CD90+, CD105+, Oct4+ and Nanog+, CD11b-, CD14-, CD34-, CD45-, HLA-DR-
Wang et al[41], 2016	NP-SCs/AF-SCs/CEP-SCs	CD73+, CD90+, CD105+, CD19-, CD34-, CD45-, HLA-DR-
Liang et al[42], 2018	NP-MSCs	CD73+, CD90+, CD105+, Sox2+ and Oct4+, CD14-, CD19-, CD34-, HLA-DR-
Daisuke et al[43], 2012	NPPCs	Tie2+, GD2+
Chen et al[44], 2018	NP-MSCs	CD73+, CD90+, CD105+, CD34-, HLA-DR-
Quan et al[48], 2015	NP-MSCs	CD29+, CD44+, CD105+, CD14-, CD34-, CD45-, HLA-DR-
Liu et al[49], 2017	AF-MSCs, NP-MSCs, CEP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-, HLA-DR-
Blanco et al[27], 2010	NP-MSCs	CD73+, CD90+, CD105+, CD106+, CD166+, CD19-, CD34-, CD45-, HLA-DR-
Lazzarini et al[50], 2018	NP-MSCs	CD13+, CD73+, CD90+, CD105+, CD11b-, CD14-, CD19-, CD45-, HLA-DR-
Pereira et al[51], 2016	CEP-MSCs	Not shown
Qi et al[57], 2018	NP-MSCs	CD24+, CD73+, CD90+, CD105+, CD29-, CD45-
Rat
Zhao et al[34], 2017	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Li et al[39], 2019	NP-MSCs	CD44+, CD73+, CD90+, CD105+, Oct4+, Nanog+ and Sox2+, CD34-, HLA-DR-
Li et al[45], 2013	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Wang et al[46], 2019	NP-MSCs	CD73+, CD90+, CD105, Tie2+, CD34-, CD45-
Nan et al[52], 2019	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Han et al[29], 2014	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Tao et al[28], 2013	NP-MSCs	CD73+, CD90+, CD105+, Nanog+, Sox2+, Rex1+ and Oct4+, CD34-, CD45-
Tao et al[53], 2015	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Liu et al[30], 2019	N-NP-MSCs/D-NP-MSCs	CD73+, CD90+, CD105+, CD166+, Sox2+, Nanog+, Oct4+, LIF+, PCNA+ and C-KIT+, CD34-, CD45-
Li et al[55], 2018	NP-MSCs	CD73+, CD90+, CD105+, CD34-, CD45-
Cheng et al[56], 2019	NP-MSCs	CD29+, CD44+, CD90+, CD34-, CD45-
Lin et al[58], 2017	NP-MSCs/NPPCs	CD29+, CD44+, CD90+, Nanog+, Oct4+ and Sox2+, CD34-, CD45-
Liu et al[68], 2019	NP-MSCs	CD73+, CD90+, CD105+, Sox2+, Nanog+ and Oct4+, CD34-, CD45-
Zhang et al[69], 2015	NP-MSCs	CD44+, CD73+, CD90+, CD105+, Sox2+, Nanog+ and Oct4+, CD14-, CD34-, CD45-, HLA-DR-
Dog
Erwin et al[47], 2013	NPPCs	Oct3/4+, Sox2+, CD133+, Nanog+ and Nestin+
Bovine
Tekari et al[63], 2016	NPPCs	Tie2+
Rabbit
Jia et al[54], 2018	NP-MSCs	CD29+, CD44+, CD166+, CD4-, CD8-, CD14-

MSC: Mesenchymal stem cell; NP: Nucleus pulposus; AF: Annulus fibrosus; CEP: Cartilaginous endplates; NPPC: NP-derived progenitor cell.