C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization

Figure 2 Exo^CCR2 improved the spatial learning and memory at day 28 after transient middle cerebral occlusion compared to Exo^Ctrl. A: Experimental schedule to observe the effects of exosomes on rats with transient middle cerebral occlusion (tMCAO); B: Effect of exosomes on the mean escape latency to find the platform in each group. n = 10, ^eP < 0.01, Exo^Ctrl vs tMCAO, ^cP < 0.001, Exo^CCR2 vs tMCAO, ^aP < 0.05, Exo^CCR2 vs Exo^Ctrl; C: Effect of exosomes on the time spent in the target quadrant in case of rats from each group. n = 10. ^dP < 0.05, ^eP < 0.01, ^fP < 0.001; D: Effect of exosomes on the mNSS values of rats from each group. n = 10. ^eP < 0.01, Exo^Ctrl vs tMCAO, ^fP < 0.001, Exo^Ctrl vs tMCAO, ^cP < 0.001, Exo^CCR2 vs tMCAO, ^aP < 0.05, Exo^CCR2 vs Exo^Ctrl.