Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly

Figure 5 Expressions of adipogenic marker and vascular endothelial growth factor A genes. The ones encoding adipogenic markers (Peroxisome proliferator-activated receptor gamma 2, patatin-like phospholipase domain-containing protein 2, Fatty acid synthase, Glycerol-3-Phosphate Dehydrogenase 1 and Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha) and vascular endothelial growth factor A were measured in mesenchymal stem cells induce to differentiate into adipocytes. Experiments were carried out in normoxia (0 hypoxia h) or cyclic hypoxia, at days 7 and 13, after adipogenic induction. ^aP < 0.05 vs normoxia (0 h of hypoxia). VEGFA: Vascular endothelial growth factor A; PPARG2: Peroxisome proliferator-activated receptor gamma 2; PNPLA2: Patatin-like phospholipase domain-containing protein 2; FASN: Fatty acid synthase; GPD1: Glycerol-3-phosphate dehydrogenase 1; and PPARGC1A: Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.