Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly

Figure 3 Quantification of gene expressions. The ones of osteoblastic markers (Runt-related transcription factor 2, Osterix, Collagen, type I, alpha 1, Integrin-binding sialoprotein and BGLAP) and Vascular endothelial growth factor A were measured in mesenchymal stem cells induce to differentiate into osteoblasts, in normoxia (0 hypoxia h) or cyclic hypoxia, at days 7 and 13 of osteogenic induction. ^aP < 0.05 vs normoxia (0 h of hypoxia). RUNX2: Runt-related transcription factor 2; SP7: Osterix; COL1A1: Collagen, type I, alpha 1; IBSP: Integrin-binding sialoprotein; and VEGFA: Vascular endothelial growth factor A.