Stem cells from human exfoliated deciduous teeth ameliorate concanavalin A-induced autoimmune hepatitis by protecting hepatocytes from apoptosis

Figure 1 Pretreatment with stem cells from human exfoliated deciduous teeth alleviates concanavalin A-induced acute liver injury in mice. A: Mice were subjected to intravenous injections with stem cells from human exfoliated deciduous teeth cells (1 × 10⁶) 7 d prior to a concanavalin A (20 mg/kg) challenge. Mice were sacrificed 1 d after injection; B: Levels of serum alanine aminotransferase; C: Levels of serum aspartate aminotransferase; D: Anatomical examination and hematoxylin-eosin staining showing necrotic area in the three groups. Arrows indicate massive cell death in the liver section; E: Percentage of liver tissue necrotic areas. Scale bars = 200 μm. ^aP < 0.05; ^bP < 0.01; n ≥ 3.