6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy

doi:10.4252/wjsc.v12.i12.1603

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Dec 26, 2020; 12(12): 1603-1622
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1603

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Figure 8 Schematic of protective effects of 6-gingerol. 6-gingerol (6-GIN) inhibits nucleus pulposus-derived mesenchymal stem cell apoptosis and extracellular matrix degeneration by promoting autophagy via the PI3K/Akt pathway under oxidative damage induced by hydrogen peroxide alone (H₂O₂ group). NP: Nucleus pulposus; 6-GIN: 6-gingerol; NPMSCs: Nucleus pulposus-derived mesenchymal stem cells; H₂O₂: Hydrogen peroxide; ROS: Reactive oxygen species.

Citation: Nan LP, Wang F, Liu Y, Wu Z, Feng XM, Liu JJ, Zhang L. 6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy. World J Stem Cells 2020; 12(12): 1603-1622
URL: https://www.wjgnet.com/1948-0210/full/v12/i12/1603.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i12.1603