Brain tumors: Cancer stem-like cells interact with tumor microenvironment

Figure 3 Targeting the vasculature presents promising effects on brain tumor therapy. Case 1 is a 29-year-old female patient who was diagnosed with IDH1/2 wild-type glioblastoma and received treatment of temozolomide combined with apatinib. Case 2 is a 31-year-old female patient who was diagnosed with recurrent medulloblastoma (local recurrence and dissemination) and received temozolomide + irinotecan + bevacizumab. A: Axial enhanced magnetic resonance imaging (MRI) showing a mass located at the left thalamus; B: Axial enhanced MRI showing that the lesion significantly progressed after 1-mo treatment of temozolomide; C: Axial enhanced MRI showing that the lesion was dramatically reduced after 1-mo treatment of combination of temozolomide and apatinib; D and E: Enhanced cerebrospinal MRI showing the local recurrent medulloblastoma and disseminated lesions along the spinal cord; F and G: Enhanced cerebrospinal MRI showing that the recurrent and disseminated lesions were significantly reduced after one cycle of chemotherapy.