Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

doi:10.4252/wjsc.v12.i11.1410

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Nov 26, 2020 (publication date) through Nov 23, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2020; 12(11): 1410-1428
Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1410

Table 2 RNAseq reveals that glutathione metabolism genes are up-regulated in cancer stem cell-enriched cultures from pancreatic cancer patient-derived xenografts

PDX	GGTs	GSTs	GPXs	Synthesis and recycling
PDX185	GGT1, GGT2, GGT3P, GGT6, GGT7	GSTA1, GSTA2, GSTT1, MGST2, MGST3	GPX2, GPX3	GCLC, GSR, PGD, IDH1
PDX215	GGT1, GGT2, GGT7, GGT8P	GSTA1, GSTA4, GSTM2, GSTM4, MGST2		OPLAH, IDH1
PDX253	GGT1, GGT2, GGT3P, GGT6	GSTA1, GSTA2, GSTA4, MGST1, MGST2, MGST3	GPX2, GPX8	GSR, IDH1
PDX354		GSTA1, GSTA2, MGST1, GSTM2	GPX3, GPX8	GCLC, GGCT, IDH1
PDX265		GSTA4, GSTM1, GSTM2, GSTM4	GPX2	GGCT, PGD, IDH1, IDH2

PDX: Patient-derived xenograft; GGTs: Gamma-glutamyltransferases; GSTs: Glutathione-s-transferases; GPXs: Glutathione peroxidases.

Citation: Jagust P, Alcalá S, Sainz Jr B, Heeschen C, Sancho P. Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells. World J Stem Cells 2020; 12(11): 1410-1428
URL: https://www.wjgnet.com/1948-0210/full/v12/i11/1410.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i11.1410