Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

doi:10.4252/wjsc.v12.i11.1410

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 11

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10720)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-6) series, Tables (1-2) series.

Item

Count

PDF

491

WORD

170

HTML

5967

Figures (1-6)

352

Tables (1-2)

240

Sum=7220

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

388

Download

899

Sum=1287

Publishing Process of This Article

Item

Count

Browse

718

Download

1495

Sum=2213

Nov 26, 2020 (publication date) through Dec 27, 2024

Times Cited of This Article

Times Cited (49)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Stem Cells. Nov 26, 2020; 12(11): 1410-1428
Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1410

Table 2 RNAseq reveals that glutathione metabolism genes are up-regulated in cancer stem cell-enriched cultures from pancreatic cancer patient-derived xenografts

PDX	GGTs	GSTs	GPXs	Synthesis and recycling
PDX185	GGT1, GGT2, GGT3P, GGT6, GGT7	GSTA1, GSTA2, GSTT1, MGST2, MGST3	GPX2, GPX3	GCLC, GSR, PGD, IDH1
PDX215	GGT1, GGT2, GGT7, GGT8P	GSTA1, GSTA4, GSTM2, GSTM4, MGST2		OPLAH, IDH1
PDX253	GGT1, GGT2, GGT3P, GGT6	GSTA1, GSTA2, GSTA4, MGST1, MGST2, MGST3	GPX2, GPX8	GSR, IDH1
PDX354		GSTA1, GSTA2, MGST1, GSTM2	GPX3, GPX8	GCLC, GGCT, IDH1
PDX265		GSTA4, GSTM1, GSTM2, GSTM4	GPX2	GGCT, PGD, IDH1, IDH2

PDX: Patient-derived xenograft; GGTs: Gamma-glutamyltransferases; GSTs: Glutathione-s-transferases; GPXs: Glutathione peroxidases.

Citation: Jagust P, Alcalá S, Sainz Jr B, Heeschen C, Sancho P. Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells. World J Stem Cells 2020; 12(11): 1410-1428
URL: https://www.wjgnet.com/1948-0210/full/v12/i11/1410.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i11.1410